Chris Hughton’s Seagulls make the trip along the South Coast searching for their first away win of the campaign
Southampton are looking to record back-to-back Premier League victories for the first time since April 2017.
Brighton are the visitors to St Marys, with the Saints buoyant from their 2-0 win at Crystal Palace before the international break.
That relieved some of the early pressure on boss Mark Hughes, who had seen his side struggle to defeats against Leicester and Everton.
The Seagulls’ one win came against Manchester United on home soil and they are yet to score away from the Amex this term.
This clash on the South Coast is the Monday night offering on September 17.
Kick-off at St Marys is at 8pm.
Last season the Seagulls went home with a point after Glenn Murray’s penalty earned them a 1-1 draw.
You can catch all the action live on Sky Sports Premier League, Main Event and Ultra HD.
Coverage will begin at 7pm.
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Southampton are sweating on the fitness of forwards Shane Long and Charlie Austin.
Danny Ings netted in the win over Palace and will be the chief goal threat for the home side.
Brighton’s chief playmaker Pascal Gross is undergoing a late fitness test after struggling with an ankle problem over the international break.